PharmVar GeneFocus: CYP2C9

descriptionPublicationkeyboard_double_arrow_right Article 12 Jul 2021 United States, Sweden English Publisher:WileyJournal:Clinical Pharmacology & Therapeutics, volume 110, pages 662-676 (issn: 0009-9236, eissn: 1532-6535,

Copyright policy )Funded by:NIH | PHARMacogene VARiation Co..., NIH | PharmGKB: pharmacogenomi..., NIH | Training Program for Appl... +2 projects

Authors: Sangkuhl, Katrin; Claudio‐Campos, Karla; Cavallari, Larisa H.; Agundez, Jose A.G.; Whirl‐Carrillo, Michelle; Duconge, Jorge; Del Tredici, Andria L.; +8 Authors

doi: 10.1002/cpt.2333

pmid: 34109627

pmc: PMC8607432

handle: 1805/27733

PharmVar GeneFocus: CYP2C9

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Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti‐inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.

Countries

United States, Sweden

Related Organizations

Uppsala University
Sweden
Stanford University
United States
Stanford University School of Medicine
United States
University of Florida
Indiana University
United States

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Keywords

Polymorphism, Genetic, Clinical Laboratory Medicine, Knowledge Bases, Pharmacogene Variation Consortium, CYP2C9 gene, Klinisk laboratoriemedicin, Haplotypes, Pharmaceutical Preparations, Pharmacogenetics, Humans, PharmVar, Genetic variation, Alleles, Cytochrome P-450 CYP2C9

1 Research products, page 1 of 1

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database
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