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Clinical Pharmacology & Therapeutics
Article . 2020 . Peer-reviewed
License: CC BY NC ND
Data sources: Crossref
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Clinical Pharmacology & Therapeutics
Article
License: CC BY NC ND
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PharmVar GeneFocus: CYP2C19

Authors: Botton, Mariana R.; Whirl-Carrillo, Michelle; Del Tredici, Andria L.; Sangkuhl, Katrin; Cavallari, Larisa H.; Agúndez, José A.; Duconge, Jorge; +8 Authors

PharmVar GeneFocus: CYP2C19

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Country
United States
Keywords

Cytochrome P-450 CYP2C19, Genotype, Haplotypes, Pharmacogenetics, Knowledge Bases, Genetic Variation, Humans, Genetic variation, Alleles

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    116
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
116
Top 1%
Top 10%
Top 1%
hybrid