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Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase Inhibitors

Authors: Jasmine M. Cross; Tim R. Blower; Natalie Gallagher; Jason H. Gill; Kimberly L. Rockley; James W. Walton;
APC: 1,698.31 EUR

Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase Inhibitors

Abstract

AbstractThe first examples of RuII and RhIII piano‐stool complex histone deacetylase (HDAC) inhibitors are presented. The novel complexes have antiproliferative activity against H460 non‐small‐cell lung carcinoma cells that is comparable to the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Strong evidence for HDAC inhibition as a primary mechanism of action is provided. The complexes reported here represent an important step towards the design of highly active and selective HDAC inhibitors.

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    popularity
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    Top 10%
    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Top 10%
Average
Top 10%
Green
hybrid
Related to Research communities
Cancer Research