Glutathione Bioresponsive Cyclodextrin Nanosponges

descriptionPublicationkeyboard_double_arrow_right Article 15 Dec 2015 Italy English Publisher:WileyJournal:ChemPlusChem, volume 81, pages 439-443 (issn: 2192-6506, eissn: 2192-6506,

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Authors: TROTTA, Francesco; CALDERA, FABRIZIO; DIANZANI, Chiara; ARGENZIANO, MONICA; BARRERA, Giuseppina; CAVALLI, Roberta;

doi: 10.1002/cplu.201500531 , 10.1002/cplu.201600105

pmid: 31968779 , 31968774

handle: 2318/1533601

Glutathione Bioresponsive Cyclodextrin Nanosponges

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Abstract

AbstractCyclodextrin‐based nanosponges are designed as new nanostructured material for drug delivery. In vitro and in vivo studies show that nanosponges can increase the effectiveness of anti‐cancer drugs encapsulated within their nanostructure. Reported is a new, cheap glutathione (GSH)‐responsive material easily obtained in high yield through a one‐step synthetic route. Effectiveness of this GSH‐responsive material was proved using several tumor cells and doxorubicin as model anticancer drug. The release of the drug was in according with the GSH content in tumor cells.

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Italy

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University of Turin
Italy

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