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A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2010 Netherlands English Publisher:WileyJournal:Contrast Media & Molecular Imaging, volume 5, pages 231-236 (issn: 1555-4309, eissn: 1555-4317,

Authors: van Schooneveld, Matti M; Cormode, David P; Koole, Rolf; van Wijngaarden, J Timon; Calcagno, Claudia; Skajaa, Torjus; Hilhorst, Jan; +4 Authors

doi: 10.1002/cmmi.376

pmid: 20812290

pmc: PMC3586549

A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

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Abstract

AbstractAn important challenge in medical diagnostics is to design all‐in‐one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X‐ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle‐enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target‐specific molecular imaging, and is a step in the direction of truly multi‐modal imaging. Copyright © 2010 John Wiley & Sons, Ltd.

Country

Netherlands

Related Organizations

Utrecht University
Netherlands
Icahn School of Medicine at Mount Sinai
United States

Keywords

Contrast Media, Silicon Dioxide, Magnetic Resonance Imaging, Fluorescence, Polyethylene Glycols, Mice, Inbred C57BL, Mice, Animals, Nanoparticles, Gold, Tomography, X-Ray Computed, Fluorescent Dyes

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	103
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%