Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro
Copyright policy )Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro
AbstractAbstract: A series of mononuclear coordination or organometallic AuI/AuIII complexes (1–9) have been comparatively studied in vitro for their antileishmanial activity against promastigotes and amastigotes, the clinically relevant parasite form, of Leishmania amazonensis and Leishmania braziliensis. One of the cationic AuI bis‐N‐heterocyclic carbenes (3) has low EC50 values (ca. 4 μM) in promastigotes cells and no toxicity in host macrophages. Together with two other AuIII complexes (6 and 7), the compound is also extremely effective in intracellular amastigotes from L. amazonensis. Initial mechanistic studies include an evaluation of the gold complexes′ effect on L. amazonensis’ plasma membrane integrity.
- Technical University of Munich (TUM) Germany
- TECHNISCHE UNIVERSITAET MUENCHEN Germany
- University of Palermo Italy
- State University of Campinas Brazil
- Technical University of Munich Germany
Leishmania, Mice, Inbred BALB C, Cultured, Molecular Structure, Cells, Antiprotozoal Agents, amastigotes, Communications, Mice, Parasitic Sensitivity Tests, gold compounds, Animals, promastigotes, antiprotozoal agents, leishmaniasis, Organogold Compounds, Inbred BALB C, Cells, Cultured
Leishmania, Mice, Inbred BALB C, Cultured, Molecular Structure, Cells, Antiprotozoal Agents, amastigotes, Communications, Mice, Parasitic Sensitivity Tests, gold compounds, Animals, promastigotes, antiprotozoal agents, leishmaniasis, Organogold Compounds, Inbred BALB C, Cells, Cultured
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