Synthesis of Somatostatin Mimetics Based on 1‐Deoxynojirimycin
Copyright policy )Synthesis of Somatostatin Mimetics Based on 1‐Deoxynojirimycin
AbstractThe synthesis of novel somatostatin mimetics from 1‐deoxynojirimycin (DNJ) is described. The dipeptide mimetic, which respectively displayed the side chains of tryptophan and lysine at the nitrogen and O6 atoms of the iminosugar scaffold is a ligand (Ki=3.2 μM) for the human somatostatin receptor subtype 4 (hSSTR4) but has lower affinity (Ki>100 μM) for hSSTR5. A benzylated analogue of the Trp‐Lys mimetic displays higher affinity for hSSTR5 (Ki=5 μM).
- University College Dublin Ireland
Models, Molecular, 1-Deoxynojirimycin, Lysine, Tryptophan, Ligands, Binding, Competitive, Hormones, Imino Sugars, Biomimetic Materials, Humans, Receptors, Somatostatin, Somatostatin
Models, Molecular, 1-Deoxynojirimycin, Lysine, Tryptophan, Ligands, Binding, Competitive, Hormones, Imino Sugars, Biomimetic Materials, Humans, Receptors, Somatostatin, Somatostatin
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