Oxime and Oxime Ether Derivatives of 1,4‐Benzothiazine Related to Oxiconazole

descriptionPublicationkeyboard_double_arrow_right Article 31 Jul 2007 Italy English Publisher:WileyJournal:ChemMedChem, volume 2, pages 1,208-1,213 (issn: 1860-7179, eissn: 1860-7187,

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Authors: MILANESE, Lara; GIACCHE', NICOLA; SCHIAFFELLA, Fausto; VECCHIARELLI, Anna; MACCHIARULO, Antonio; FRINGUELLI, Renata;

doi: 10.1002/cmdc.200700066

pmid: 17541993

handle: 11391/152924

Oxime and Oxime Ether Derivatives of 1,4‐Benzothiazine Related to Oxiconazole

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Abstract

AbstractThe synthesis, in vitro antifungal activity, and molecular docking experiments of some oxime and oxime ether derivatives of azole 1,4‐benzothiazine are reported herein, with the aim of evaluating the influence of a partially constrained scaffold that is structurally related to Oxiconazole and bearing the 1,4‐benzothiazine moiety, on the inhibition of Candida albicans CYP51.

Country

Italy

Related Organizations

University of Perugia
Italy

Keywords

Antifungal Agents, Magnetic Resonance Spectroscopy, Imidazoles, Thiazines, Microbial Sensitivity Tests, Structure-Activity Relationship, Candida albicans, Oximes, Ethers

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