AbstractRecent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network. Laborious investigations in the association between both components, may reveal new targets for opposing severe human disease, including the acute respiratory distress syndrome.