A cohort of 12 cases of reported TCM andCR was identified and compared to a group without rup-ture selected by random sampling. Rupture was confirmedon autopsy in 5 patients, suspected by catheterization in2 patients,andsuggestedbyechocardiographyin5patients.MorepatientswithCRhadSTelevationinleadIIandwereallolder females (76±9 years). Also, systolic blood pressure,double product, and peak creatine kinase were significantlyhigher in the CR group compared to controls. However,the difference in troponin I was not statistically significant.Furthermore, the use of β-blockers was less frequent in theCR group. These features of rupture in TCM are similarto those known to occur with rupture following myocardialinfarction (MI).TCM tends to have a clinical presentation similar toan acute MI, with substernal chest pain and dyspnea andmild elevation of markers of myocardial necrosis. The diag-nosis will ultimately depend on demonstrating the lackof occlusive coronary lesions with matching wall motionabnormalities.