AbstractCardiac resynchronization therapy (CRT) is a new method for the correction of inter‐ and/or intraventricular conduction delays of patients with heart failure. The long‐term impact of CRT on central hemodynamics is not fully characterized. We performed complete right heart catheterization studies in 31 patients receiving a CRT device pre and 6 months after implantation. Most of the patients improved in their NYHA stage, their LVEF, and in parallel showed reduced right atrial (RA) pulmonary artery (PA) and pulmonary capillary wedge (PCW) pressures and pulmonary vascular resistance both at rest and at 25 watts. In addition, we found a reduction in heart rate accompanied by an increased mean arterial pressure both at rest and at 25 watts. Accordingly, brain natriuretic peptide levels (BNP) were lowered. It was concluded that, besides other well‐known effects on ventricular coordination, central hemodynamics after 6 months were improved during CRT. Copyright © 2007 Wiley Periodicals, Inc.