Regio‐specific Microbial Hydroxylation of Phytolaccagenin by Streptomyces griseus ATCC 13273

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2009 English Publisher:WileyJournal:Chinese Journal of Chemistry, volume 27, pages 1,434-1,436 (issn: 1001-604X, eissn: 1614-7065,

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Authors: Liwu QIAN; Jian ZHANG; Jihua LIU; Boyang YU;

doi: 10.1002/cjoc.200990241

Regio‐specific Microbial Hydroxylation of Phytolaccagenin by Streptomyces griseus ATCC 13273

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Abstract

AbstractMicrobial transformation of one oleane‐type pentacyclic triterpene aglycone, phytolaccagenin (2β,3β,23‐trihydroxy‐olean‐12‐ene‐28,30‐dioic acid 30‐methyl ester) by Streptomyces griseus ATCC 13273 was investigated for developing new bioactive derivatives. A new oxidized metabolite, through the regio‐specific hydroxylation on the C‐29 methyl group, was obtained from the preparative‐scale biotransformation with a standard two‐stage fermentation protocol. The metabolite was identified as 2β,3β,23,29‐tetrahydroxy‐olean‐12‐ene‐28,30‐dioic acid 30‐methyl ester by mass and 2D‐NMR spectra.

Related Organizations

China Pharmaceutical University
China (People's Republic of)

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