Improved Preparation of Tyramine by Curtius Rearrangement

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2009 English Publisher:WileyJournal:Chinese Journal of Chemistry, volume 27, pages 433-436 (issn: 1001-604X, eissn: 1614-7065,

Copyright policy )

Authors: Yun LI; Fan YANG; Xiaoying XU; Shiyin PAN; Lixin WANG; Chuanqin XIA;

doi: 10.1002/cjoc.200990072

Improved Preparation of Tyramine by Curtius Rearrangement

- Summary
- Metrics

Abstract

AbstractAn improved and facile preparation of tyramine [2‐(p‐hydroxyphenyl)ethylamine] was described, which starts from phenol and acrylonitrile to form β‐(p‐hydroxyphenyl) propionic acid via Friedel‐Craft's alkylation and nitrile hydrolysis. After hydrazinolysis and a subsequent Curtius rearrangement, tyramine was obtained in 30.2% total yield.

Related Organizations

Chengdu Organic Chemicals (China)
China (People's Republic of)
Sichuan University
China (People's Republic of)
Chinese Academy of Sciences
China (People's Republic of)

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	8
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average