An Improved and Efficient Process for the Preparation of (+)‐cloprostenol

descriptionPublicationkeyboard_double_arrow_right Article 12 May 2015 English Publisher:WileyJournal:Chirality, volume 27, pages 392-396 (issn: 0899-0042, eissn: 1520-636X,

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Authors: Yi, Chen; Hui, Yan; Hui-Xuan, Chen; Jiang, Weng; Gui, Lu;

doi: 10.1002/chir.22457

pmid: 25965955

An Improved and Efficient Process for the Preparation of (+)‐cloprostenol

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Abstract

AbstractAn improved and efficient synthesis of (+)‐cloprostenol has been accomplished in nine steps and 26% overall yield from commercially available (–)‐Corey lactone 4‐phenylbenzoate alcohol 1. The present route avoids tedious purifications and requires only one column chromatography operation, which reduces the generation of waste and is suitable for large‐scale preparation. Chirality 27:392–396, 2015. © 2015 Wiley Periodicals, Inc.

Related Organizations

Sun Yat-sen University
China (People's Republic of)

Keywords

Molecular Structure, Drug Evaluation, Preclinical, Cloprostenol, Stereoisomerism, Chromatography, Liquid

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