Vibrational Circular Dichroism (VCD), VCD Exciton Coupling, and X‐ray Determination of the Absolute Configuration of an α,β‐Unsaturated Germacranolide
Copyright policy )Vibrational Circular Dichroism (VCD), VCD Exciton Coupling, and X‐ray Determination of the Absolute Configuration of an α,β‐Unsaturated Germacranolide
AbstractThe absolute configuration of 1 was deduced by vibrational circular dichroism together with the evaluation of the Flack and Hooft X‐ray parameters. Vibrational circular dichroism exciton coupling, using the carbonyl group signals, confirmed the absolute configuration of 2. In addition, sodium borohydride reduction of the 11,13‐double bond of 6‐epi‐desacetyllaurenobiolide (1) yields an almost equimolecular mixture of C11 epimers, while reduction of the same double bond of 6‐epi‐laurenobiolide (2) provided almost exclusively the (11S) diastereoisomer 4. Chirality 27:247–252, 2015. © 2015 Wiley Periodicals, Inc.
Sesquiterpenes, Germacrane, X-Ray Diffraction, Circular Dichroism, Molecular Conformation, Vibration
Sesquiterpenes, Germacrane, X-Ray Diffraction, Circular Dichroism, Molecular Conformation, Vibration
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