Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells
Copyright policy )Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells
ABSTRACTThe stereoselective uptake of propranolol enantiomers was investigated by using the K562 and K562 adriamycin‐resistant cell line (K562/ADR) as a model. An enantioselective RP‐HPLC method was applied to determine the accumulation of propranolol (PPL) stereoisomers in K562 and K562/ADR cells. The concentration, time and temperature dependent studies showed that the accumulation of S‐(−)‐PPL was higher than R‐(+)‐PPL in K562 cells and uptake of R‐(+)‐PPL was significantly higher than that of S‐(−)‐PPL in K562/ADR cells. The results indicate the enantioselective accumulation of propranolol enantiomers in K562 and K562 / ADR cells.Chirality 25:361–364, 2013. © 2013 Wiley Periodicals, Inc.
- China Pharmaceutical University China (People's Republic of)
- Zhejiang Ocean University China (People's Republic of)
- Bloodworks Northwest United States
Molecular Structure, Humans, Stereoisomerism, K562 Cells, Propranolol, Chromatography, High Pressure Liquid
Molecular Structure, Humans, Stereoisomerism, K562 Cells, Propranolol, Chromatography, High Pressure Liquid
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