AbstractIn order to reasonably make full use of the advantages of different steels and then achieve a steel structure with excellent seismic behaviour, the authors proposed novel triple grades hybrid high‐performance steel structures (TGHSSs) comprising high‐strength steel (HSS) columns, ordinary‐strength steel beams, and low‐yield‐point (LYP) steel buckling‐restrained braces (BRBs). The basic concept and expected advantages were introduced. To validate this concept, eight full‐scale single‐bay two‐storey TGHSS specimens were tested under cyclic loads, in which columns are of 460 MPa, 690 MPa, and 890 MPa HSSs, beams are of 345 MPa steel, and BRBs are of 100 MPa, 160 MPa, and 225 MPa LYP steels. Meantime, nine LYP steel BRB specimens were taken out and tested under uniaxial cyclic loads. Based on the experimental study, numerical simulation and parametric analyses on TGHSSs were further conducted, and a performance‐based design method was proposed. Results indicated that the TGHSSs featured a sequential yielding mechanism with excellent seismic performance. Specifically, the LYP steel BRBs yielded at first to dissipate seismic energy. Then, the ordinary‐strength steel beams developed plastic hinges at beam ends. At last, the HSS columns kept almost elastic or presented limited plasticity at column bases. This research proves such a high‐performance structure with a reasonable combination of high, ordinary, and low strength steels, whose advantages can be fully developed.