AbstractRoutine, large‐scale monitoring, such as point‐of‐care systems, requires inexpensive and simple analytical schemes. An electroanalytical concept of biamperometry for such sensing systems has been overlooked due to widespread potentiostat‐controlled experiments. Herein, biamperometry is introduced as a powerful tool. In particular, its ability to eliminate electrochemical interference is highlighted for a case study on employing [Fe(CN)6]4−/[Fe(CN)6]3−, aminoferrocene (Fe2+)/[Ru(NH3)6]3+, and ascorbic acid as two redox pairs and one interfering compound, respectively. A specific signal 15 times higher than that of an unspecific signal is observed, even under unfavorable conditions such as a 1:5 molar ratio of specific‐to‐interfering redox entities. This system is successfully used to determine glucose in blood plasma. A further promising usage of biamperometry is illustrated by the study of an unstable redox system: the oxygen‐dependent oxidation of [Ru(NH3)6]2+ in an aqueous environment.