AbstractOn the one hand, Fenton‐like reactions are common side reactions in electrocatalytic oxygen reduction reaction (ORR). The generated reactive oxygen species (ROS) could damage the active sites of single‐atom catalysts (SACs), thereby affecting the stability of the catalysts. On the other hand, the Fenton‐like reaction could generate radicals with strong oxidative properties, which could be used in the degradation of pollutants and tumor therapy. In this review, we summarize strategies to limit the occurrence of Fenton‐like reactions and improve the stability of SACs. In addition, the promotion of Fenton‐like reactivity of SACs and its application in related fields are also concluded.