AbstractGraphene oxide promotes the oxidative degradation of α‐guaiacylglycerol‐β‐guaiacyl ether, a lignin model compound, in different solvents including acetonitrile, toluene and water mainly to guaiacol, 2‐methoxyquinone, vanillic acid and coniferyl aldehyde. Reduced graphene oxide and B‐doped graphene exhibit similar activity as graphene oxide. Control experiments indicate that metal impurities should play a marginal role in the observed catalytic activity.