AbstractObjectivesThis study aimed to assess the risk stratification value of the SYNTAX Score II (SS II) in consecutive PCI patients and to analyze whether the predictive ability of SS II was consistent in patients with complex and non‐complex coronary artery disease.BackgroundSS II was designed for patients with complex coronary artery disease and has been validated by a number of studies in such patients.MethodsThe SS II for PCI was assessed in 10,072 consecutive patients who underwent PCI in Fuwai Hospital from January to December 2013. The patients were stratified according to SS II tertiles and divided into two subgroups: one‐vessel or two‐vessel disease (1 or 2VD) group (n = 5,709) and left main (LM) and/or three‐vessel disease (3VD) group (n = 4,363). The endpoint was 30‐month all‐cause death following PCI procedure.ResultsThe high SS II group showed significantly higher 30‐month mortality. Multivariate analyses showed that in the all‐patients cohort and the two subgroups, SS II was an independent predictor of 30‐month mortality (P < 0.0001). Based on receiver operating characteristic curves analysis, SS II showed moderate discrimination ability for 30‐month mortality (C‐statistics = 0.68, Hosmer–Lemeshow test P value >.05) and appeared to have better discrimination ability in the LM and/or 3VD subgroup (C‐statistics = 0.631 vs. 0.722 for 1 or 2VD and LM and/or 3VD subgroups).ConclusionsSS II was able to risk‐stratify patients and predict 30‐month mortality in all PCI patients. The discrimination ability of SS II appeared to be better in the LM and/or 3VD subgroup.