Vinculin, cell mechanics and tumour cell invasion

descriptionPublicationkeyboard_double_arrow_right Article 13 Mar 2013 English Publisher:WileyJournal:Cell Biology International, volume 37, pages 397-405 (issn: 1065-6995, eissn: 1095-8355,

Copyright policy )

Authors: Wolfgang H, Goldmann; Vera, Auernheimer; Ingo, Thievessen; Ben, Fabry;

doi: 10.1002/cbin.10064

pmid: 23494917

Vinculin, cell mechanics and tumour cell invasion

- Summary
- Subjects
- Metrics

Abstract

AbstractThe focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.

Related Organizations

University of Erlangen-Nuremberg
Germany

Keywords

Carcinogenesis, Cell Movement, Neoplasms, Cell Adhesion, Animals, Humans, Apoptosis, Actins, Vinculin, Signal Transduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	87
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%