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ChemBioChem
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https://dx.doi.org/10.25418/cr...
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License: CC BY
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Article . 2023
License: CC BY
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ChemBioChem
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Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy

Authors: Thomas W. Rees; Po‐Yu Ho; Jeannine Hess;

Recent Advances in Metal Complexes for Antimicrobial Photodynamic Therapy

Abstract

AbstractAntimicrobial resistance (AMR) is a growing global problem with more than 1 million deaths due to AMR infection in 2019 alone. New and innovative therapeutics are required to overcome this challenge. Antimicrobial photodynamic therapy (aPDT) is a rapidly growing area of research poised to provide much needed help in the fight against AMR. aPDT works by administering a photosensitizer (PS) that is activated only when irradiated with light, allowing high spatiotemporal control and selectivity. The PS typically generates reactive oxygen species (ROS), which can damage a variety of key biological targets, potentially circumventing existing resistance mechanisms. Metal complexes are well known to display excellent optoelectronic properties, and recent focus has begun to shift towards their application in tackling microbial infections. Herein, we review the last five years of progress in the emerging field of small‐molecule metal complex PSs for aPDT.

Related Organizations
Keywords

Chemical Biology & High Throughput, Photosensitizing Agents, Photochemotherapy, Anti-Infective Agents, Coordination Complexes, Reviews, Humans, Infectious Disease, Bacterial Infections, Biochemistry & Proteomics, Structural Biology & Biophysics

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
42
Top 10%
Top 10%
Top 1%
Green
hybrid