Simple “On‐Demand” Production of Bioactive Natural Products
Copyright policy )Simple “On‐Demand” Production of Bioactive Natural Products
AbstractExchange of the native promoter to the arabinose‐inducible promoter PBAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the “on‐demand” production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel “mevalagmapeptides” and the highly toxic xenorhabdins were identified by this approach.
- Goethe University Frankfurt Germany
- Swiss Tropical and Public Health Institute Switzerland
- University of Basel Switzerland
Biological Products, Arabinose, Xenorhabdus, Cell Line, Rats, Multigene Family, Animals, Genetic Engineering, Photorhabdus, Promoter Regions, Genetic, Plasmids
Biological Products, Arabinose, Xenorhabdus, Cell Line, Rats, Multigene Family, Animals, Genetic Engineering, Photorhabdus, Promoter Regions, Genetic, Plasmids
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