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ChemBioChem
Article . 2013 . Peer-reviewed
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ChemBioChem
Article . 2014
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https://dx.doi.org/10.1002/cbi...
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Optimization of a Small Laccase by Active‐Site Redesign

descriptionPublicationkeyboard_double_arrow_right Article 14 Jun 2013 English Publisher:WileyJournal:ChemBioChem, volume 14, pages 1,209-1,211 (issn: 1439-4227, eissn: 1439-7633, Copyright policy )
Authors: Miguel D, Toscano; Leonardo, De Maria; Sune, Lobedanz; Lars H, Ostergaard;

doi: 10.1002/cbic.201300256

pmid: 23775916

Optimization of a Small Laccase by Active‐Site Redesign

Abstract

Small but faster: A small laccase from Streptomyces coelicolor (SLAC) has been engineered by structure-based design and site-directed mutagenesis to improve the activity on commercially relevant substrates. The variants generated showed up to 40-fold increased efficiency on 2,6-dimethoxyphenol and the ability to use mediators with considerably higher redox potentials (methylsyringate and TEMPO).

Related Organizations
Keywords

Models, Molecular, Catalytic Domain, Laccase, Protein Engineering, Biotransformation, Substrate Specificity

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
33
Top 10%
Top 10%
Top 10%
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