Glycosynthase‐Mediated Assembly of Xylanase Substrates and Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 27 Jun 2011 English Publisher:WileyJournal:ChemBioChem, volume 12, pages 1,703-1,711 (issn: 1439-4227, eissn: 1439-7633,

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Authors: Ethan D, Goddard-Borger; Brigitte, Fiege; Emily M, Kwan; Stephen G, Withers;

doi: 10.1002/cbic.201100229

pmid: 21710681

Glycosynthase‐Mediated Assembly of Xylanase Substrates and Inhibitors

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Abstract

AbstractAn exo‐β‐xylosidase mutant with glycosynthase activity was created to aid in the synthesis of xylanase substrates and inhibitors. Simple monosaccharides were easily elaborated into di‐, tri‐ and tetrasaccharides by using this enzyme. Some products proved to be surprisingly potent inhibitors of xylanases from glycoside hydrolase families 10 and 11.

Related Organizations

University of Lübeck
Germany
University of British Columbia
Canada

Keywords

Models, Molecular, Xylosidases, Glycoside Hydrolases, Mutagenesis, Site-Directed, Bacillus, Disaccharides, Trisaccharides

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