Cell‐Permeable β‐Peptide Inhibitors of p53/hDM2 Complexation
Copyright policy )Cell‐Permeable β‐Peptide Inhibitors of p53/hDM2 Complexation
AbstractLook at what the cat(ionic motif) dragged in! We report a general strategy to increase the cell permeability of β3‐peptides. Introduction of a minimal cationic motif within the folded structure of a high‐affinity β3‐peptide ligand for hDM2 led to molecules with high 314‐helical structure, high hDM2 affinity and sufficient cell permeability to upregulate p53‐dependent genes in live mammalian cells. Minimally cationic β3‐peptides represent the critical first step towards a class of protease‐resistant peptidomimetics that might modulate intracellular biological pathways.magnified image
- Yale University United States
Cell Membrane Permeability, Microscopy, Confocal, Circular Dichroism, Humans, RNA-Binding Proteins, Tumor Suppressor Protein p53, HCT116 Cells, Peptides, Protein Binding
Cell Membrane Permeability, Microscopy, Confocal, Circular Dichroism, Humans, RNA-Binding Proteins, Tumor Suppressor Protein p53, HCT116 Cells, Peptides, Protein Binding
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