The cover picture shows fully modified locked nucleic acids (LNAs, orange) and intercalating nucleic acids (INAs®, red) with several insertions of (R)‐1‐O‐(1‐pyrenylmethyl)glycerol, both displaying higher binding affinity to native DNA (white) than to each other. In their full paper on p. 1673 ff, E. B. Pedersen et al. describe the design of easily denaturing nucleic acid duplexes using complementary LNAs and INAs, and how the combined use of these chemically modified nucleic acids can solve the problem of "quenching" due to complementary strands of duplexes or hairpins that otherwise limit their use for DNA targeting.