Dual inhibitory effect of bredinin
Copyright policy )Dual inhibitory effect of bredinin
AbstractBredinin inhibition of cell growth was investigated in the mouse lymphoma cell line L5178Y. Bredinin caused the accumulation of IMP and the reduction of XMP. It was converted to the 5′‐phosphate within the cells. Bredinin 5′‐phosphate but not bredinin competitively inhibited both IMP dehydrogenase and GMP synthetase. Thus the inhibition of cell growth is probably due to bredinin 5′‐phosphate, which inhibits the consecutive enzyme reactions IMP dehydrogenase and GMP synthetase. These inhibitions result in the accumulation of IMP and the reduction of XMP.
- Tokai University Japan
Antibiotics, Antineoplastic, Animals, Rats, Inbred Strains, Ribonucleosides, Carcinoma 256, Walker, Leukemia L5178, Growth Inhibitors, Rats
Antibiotics, Antineoplastic, Animals, Rats, Inbred Strains, Ribonucleosides, Carcinoma 256, Walker, Leukemia L5178, Growth Inhibitors, Rats
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