Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)
Copyright policy )Pumilol, a Diterpenoid with a Rare Strobane Skeleton from Pinus pumila (Pinaceae)
Pumilol (1), a strobane diterpenoid, reported herein for the first time, was isolated from the bark of Pinus pumila (Pall.) Regel (Siberian Dwarf Pine or Japanese Stone Pine), along with 17 known compounds including serratane triterpenoids, not previously reported from this species, and four ferulate derivatives. The absolute configuration of pumilol was established using HR‐ESI‐MS, NMR, the DP4+ probabilities and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Labda‐8(17),13‐dien‐15‐oic acid (4), bornyl (E)‐4‐hydroxycinnamate (14) and bornyl (E)‐ferulate (15) showed activity against S. aureus and/or E. faecalis with MIC90 values 12.5 – 50 μm.
- University of Helsinki Finland
- University of South Africa South Africa
- University of Surrey United Kingdom
- University of KwaZulu-Natal South Africa
Models, Molecular, Staphylococcus aureus, TERPENOIDS, Molecular Conformation, Pharmacy, electronic circular dichroism, Enterococcus faecalis, Humans, Gram-Positive Bacterial Infections, strobane, Pinus pumila, DP4+probability, serratane triterpenoid, Staphylococcal Infections, Pinus, Anti-Bacterial Agents, BARK, Chemical sciences, ACID, Plant Bark, POPULATIONS, pumilol, Diterpenes
Models, Molecular, Staphylococcus aureus, TERPENOIDS, Molecular Conformation, Pharmacy, electronic circular dichroism, Enterococcus faecalis, Humans, Gram-Positive Bacterial Infections, strobane, Pinus pumila, DP4+probability, serratane triterpenoid, Staphylococcal Infections, Pinus, Anti-Bacterial Agents, BARK, Chemical sciences, ACID, Plant Bark, POPULATIONS, pumilol, Diterpenes
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