AbstractInvestigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α‐epoxysuaveolic acid (2), and 14‐O‐methylsuaveolic acid (3), together with eleven known compounds. The structures of 1–3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities.