Synthesis of Novel Derivatives of Esculentoside A and Its Aglycone Phytolaccagenin, and Evaluation of Their Haemolytic Activity and Inhibition of Lipopolysaccharide‐Induced Nitric Oxide Production

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2011 English Publisher:WileyJournal:Chemistry & Biodiversity, volume 8, pages 1,833-1,852 (issn: 1612-1872, eissn: 1612-1880,

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Authors: Wei, Gong; Zhihui, Jiang; Peng, Sun; Ling, Li; Yongsheng, Jin; Lucheng, Shao; Wen, Zhang; +6 Authors

doi: 10.1002/cbdv.201000339

pmid: 22006712

Synthesis of Novel Derivatives of Esculentoside A and Its Aglycone Phytolaccagenin, and Evaluation of Their Haemolytic Activity and Inhibition of Lipopolysaccharide‐Induced Nitric Oxide Production

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Abstract

AbstractA series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)‐induced NO production, haemolytic activity, and cell viability was evaluated. Structureactivity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS‐induced NO production, and lower haemolytic activities than esculentoside A and its derivatives.

Related Organizations

Second Military Medical University
China (People's Republic of)
Changhai Hospital
China (People's Republic of)
General Hospital of Shenyang Military Region
China (People's Republic of)

Keywords

Lipopolysaccharides, Erythrocytes, Molecular Structure, Cell Survival, Hemolytic Agents, Macrophages, Drug Evaluation, Preclinical, Saponins, Nitric Oxide, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Animals, Rabbits, Oleanolic Acid, Phytolacca

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