Bioactive Marine Prostanoids from Octocoral Clavularia viridis
Copyright policy )Bioactive Marine Prostanoids from Octocoral Clavularia viridis
AbstractChemical investigation of the nonpolar extract of soft coral Clavularia viridis resulted in isolation of five new prostanoids, designated as claviridic acids A–E (1–5, resp.), in addition to the known clavulones I–III. Their structures were determined on the basis of spectroscopic techniques, especially HR‐ESI‐MS, CD, and 2D‐NMR experiments. The isolated marine prostanoids exhibited potent inhibitory effect on PHA‐induced proliferation of peripheral blood mononuclear cells (PBMC), as well as significant cytotoxic activity against human gastric cancer cells (AGS).
Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Molecular Structure, Leukocytes, Prostaglandins, Animals, Humans, Anthozoa, Cells, Cultured, Cell Proliferation
Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Molecular Structure, Leukocytes, Prostaglandins, Animals, Humans, Anthozoa, Cells, Cultured, Cell Proliferation
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