Sinuladiterpenes A–F, New Cembrane Diterpenes from Sinularia flexibilis
Copyright policy )Sinuladiterpenes A–F, New Cembrane Diterpenes from Sinularia flexibilis
AbstractChromatographic investigation of the octocoral Sinularia flexibilis afforded six new cembrane diterpenes, sinuladiterpenes A–F (1–6, resp.), in addition to four known cembranolides, 11‐episinulariolide acetate, 11‐dehydrosinulariolide, 11‐episinulariolide, and sinulariolide. Their structures were elucidated by spectroscopic analysis, especially 2D‐NMR and HR‐ESI‐MS. Compound 2 exhibited significant in vitro cytotoxic activity against human colon adenocarcinoma (WiDr) cell line.
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Molecular Conformation, Antineoplastic Agents, Anthozoa, Cell Line, Tumor, Animals, Humans, Diterpenes, Drug Screening Assays, Antitumor, HeLa Cells
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Molecular Conformation, Antineoplastic Agents, Anthozoa, Cell Line, Tumor, Animals, Humans, Diterpenes, Drug Screening Assays, Antitumor, HeLa Cells
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