Two New Taxoids fromTaxus chinensis
Copyright policy )Two New Taxoids fromTaxus chinensis
Two new taxoids, 2,20-O-diacetyltaxumairol N (1) and 14beta-hydroxy-10-deacetyl-2-O-debenzoylbacatin III (2), were isolated from the needles and stems of Taxus chinensis. Their structures were determined on the basis of extensive 1D- and 2D-NMR-spectral analysis. Compound 1 showed weak cytotoxicity activity against T-24 (IC50 = 34 microg/ml) and QGY-7701 (IC50 = 22 microg/ml) cancer lines. Compound 2 showed no obvious cytotoxicity activity against T-24 (IC50 > 100 microg/ml) and QGY-7701 (IC50 > 100 microg/ml) cancer lines.
- Chinese Academy of Sciences China (People's Republic of)
- Kunming Institute of Botany China (People's Republic of)
Inhibitory Concentration 50, Molecular Structure, Cell Line, Tumor, Humans, Taxoids, Taxus, Antineoplastic Agents, Phytogenic
Inhibitory Concentration 50, Molecular Structure, Cell Line, Tumor, Humans, Taxoids, Taxus, Antineoplastic Agents, Phytogenic
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