Antileishmanial Physalins fromPhysalis minima

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2005 English Publisher:WileyJournal:Chemistry & Biodiversity, volume 2, pages 1,164-1,173 (issn: 1612-1872, eissn: 1612-1880,

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Authors: M. Iqbal Choudhary; Sammer Yousaf; Shakil Ahmed; null Samreen; Kauser Yasmeen; null Atta-ur-Rahman;

doi: 10.1002/cbdv.200590086

pmid: 17193198

Antileishmanial Physalins fromPhysalis minima

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Abstract

Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses. Compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.

Related Organizations

International Center for Chemical and Biological Sciences
Pakistan
University of Karachi
Pakistan

Keywords

Leishmania, Lactones, Molecular Structure, Physalis, Animals, Steroids

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