Hepatocyte nuclear factor 1 beta: A perspective in cancer
Copyright policy )Hepatocyte nuclear factor 1 beta: A perspective in cancer
AbstractHepatocyte nuclear factor 1 beta (HNF1 β/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity‐onset diabetes of the young (MODY), HNF1β expression deregulation and single nucleotide polymorphisms in HNF1β have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1α. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.
- Translational Research Institute Australia
- QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT Australia
- Queensland University of Technology Australia
Male, Organogenesis, Breast Neoplasms, Polymorphism, Single Nucleotide, Epigenesis, Genetic, Neoplasms, 616, 617, Biomarkers, Tumor, cancer, Humans, Hepatocyte Nuclear Factor 1-alpha, transcription factor, RC254-282, Cancer Biology, Hepatocyte Nuclear Factor 1-beta, Ovarian Neoplasms, splice variants, hepatocyte nuclear factor 1beta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, DNA Methylation, Endometrial Neoplasms, Neoplasm Proteins, Pancreatic Neoplasms, Alternative Splicing, Diabetes Mellitus, Type 2, Hepatocyte Nuclear Factor 4, Female, Multiple Myeloma
Male, Organogenesis, Breast Neoplasms, Polymorphism, Single Nucleotide, Epigenesis, Genetic, Neoplasms, 616, 617, Biomarkers, Tumor, cancer, Humans, Hepatocyte Nuclear Factor 1-alpha, transcription factor, RC254-282, Cancer Biology, Hepatocyte Nuclear Factor 1-beta, Ovarian Neoplasms, splice variants, hepatocyte nuclear factor 1beta, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, DNA Methylation, Endometrial Neoplasms, Neoplasm Proteins, Pancreatic Neoplasms, Alternative Splicing, Diabetes Mellitus, Type 2, Hepatocyte Nuclear Factor 4, Female, Multiple Myeloma
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!