Rapid and quantitative blood amino acid analysis by chemical ionization mass spectrometry

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1977 English Publisher:WileyJournal:Biological Mass Spectrometry, volume 4, pages 178-181 (issn: 1052-9306, eissn: 1096-9888,

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Authors: J M, Mee; J, Korth; B, Halpern; L B, James;

doi: 10.1002/bms.1200040310

pmid: 890078

Rapid and quantitative blood amino acid analysis by chemical ionization mass spectrometry

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Abstract

A quantitative analysis of amino acids in microsamples of dried blood spots by chemical ionization mass spectrometry has been developed. Isotope ratio determination was used as the quantitating technique via multiple labelled internal standards. This procedure yields excellent precision and accuracy as demonstrated by the analysis of known amino acid mixtures and of phenylalanine in the blood from newborns.

Related Organizations

Australian National University
Australia
University of Wollongong
Australia

Keywords

Phenylalanine, Phenylketonurias, Infant, Newborn, Humans, Amino Acids, Mass Spectrometry

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