AbstractInter‐ and intramolecular forces and thermodynamics are concepts usually presented early within introductory biochemistry and have relevance to many topics throughout the remainder of the course. For this reason, it is important to have a good foundation in these concepts so they can be applied to many systems. To this end, a group problem has been developed that allows students to analyze thermodynamic data and, using their knowledge of inter‐ and intramolecular forces, gain an understanding of the elements involved in the thermodynamic stability and folding of a peptide.