The PIPS special issue features sixteen original research articles and four review articles. This issue gives a healthy slice of the science presented and inspired by the PIPS meeting as it pays homage to the pioneers, who participated at the meeting. The scientific rapport, festive environment, and educational content of this meeting in Paris inspired enjoyable, productive and fruitfulconversations and insightful discoveries. May this issue provide similar pleasure and inspiration for the readership to benefit from dissemination of some of the highlights from the Peptides in Paris Symposium 2014.