Targeting duplex DNA with DNA‐PNA chimeras? Physico‐chemical characterization of a triplex DNA‐PNA/DNA/DNA
Copyright policy )Targeting duplex DNA with DNA‐PNA chimeras? Physico‐chemical characterization of a triplex DNA‐PNA/DNA/DNA
AbstractTargeting double‐stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA‐PNA chimeras. A 16‐mer 5′‐DNA‐3′‐p‐(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all‐DNA complex. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004
Models, Molecular, Peptide Nucleic Acids, DNA-PNA chimeras; triplex structure; circular dichroism; differential scanning calorimetry; molecular modeling, DNA-PNA chimeras, Chemical Phenomena, Molecular Structure, molecular modeling, Chemistry, Physical, Chimera, Circular Dichroism, Temperature, Hydrogen Bonding, Circular dichroism; Differential scanning calorimetry; DNA-PNA chimeras; Molecular modeling; Triplex structure;, DNA, Hydrogen-Ion Concentration, circular dichroism, Oligodeoxyribonucleotides, Nucleic Acid Conformation, Thermodynamics, Pyrimidine Nucleotides, triplex structure, differential scanning calorimetry
Models, Molecular, Peptide Nucleic Acids, DNA-PNA chimeras; triplex structure; circular dichroism; differential scanning calorimetry; molecular modeling, DNA-PNA chimeras, Chemical Phenomena, Molecular Structure, molecular modeling, Chemistry, Physical, Chimera, Circular Dichroism, Temperature, Hydrogen Bonding, Circular dichroism; Differential scanning calorimetry; DNA-PNA chimeras; Molecular modeling; Triplex structure;, DNA, Hydrogen-Ion Concentration, circular dichroism, Oligodeoxyribonucleotides, Nucleic Acid Conformation, Thermodynamics, Pyrimidine Nucleotides, triplex structure, differential scanning calorimetry
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