The roles of cyclin‐dependent kinase 5 in dendrite and synapse development
Copyright policy )The roles of cyclin‐dependent kinase 5 in dendrite and synapse development
AbstractSince the isolation of cyclin‐dependent kinase 5 (Cdk5), this proline‐directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Recently, a number of players implicated in dendrite and synapse development have been identified as Cdk5 substrates. Neurite extension, synapse and spine maturation are all modulated by a myriad of extracellular guidance cues or trophic factors. Cdk5 was recently demonstrated to regulate signaling downstream of some of these extracellular factors, in addition to modulating Rho GTPase activity, which regulates cytoskeletal dynamics. In this communication, we summarize our existing knowledge on the pathways and mechanisms through which Cdk5 affects dendrite, synapse and spine development.
- Biotechnology Research Institute China (People's Republic of)
- Hong Kong University of Science and Technology (香港科技大學) China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- HONG KONG POLYTECHNIC UNIVERSITY China (People's Republic of)
- Hong Kong University of Science and Technology Hong Kong
Cdk5 Protein, 571, Chemicals And Cas Registry Numbers: Neurotropin, 57657-35-9, Nerve Tissue Proteins, Chemicals And Cas Registry Numbers: Neurotropin, Trk receptors, Cell Enlargement, Cdk5 Protein, Human, 2.7.1.37, Cyclin-Dependent Kinase 5 - metabolism, Rho GTPases, Animals, Humans, 2.7.1.37, Eph receptors, Semaphorin 3A, Phosphorylation, Nerve Tissue Proteins - metabolism, 167821-03-6, Dentritic spines, Dendrites - physiology, Neurite outgrowth, Brain, 516536-20-2, Cyclin-Dependent Kinase 5, Brain - enzymology, Dendrites, 57657-35-9, Synapses - physiology, Synapses, Semaphorin 3A, 167821-03-6, 516536-20-2, Cyclin-Dependent Kinase 5, 2.7.1.37, Human
Cdk5 Protein, 571, Chemicals And Cas Registry Numbers: Neurotropin, 57657-35-9, Nerve Tissue Proteins, Chemicals And Cas Registry Numbers: Neurotropin, Trk receptors, Cell Enlargement, Cdk5 Protein, Human, 2.7.1.37, Cyclin-Dependent Kinase 5 - metabolism, Rho GTPases, Animals, Humans, 2.7.1.37, Eph receptors, Semaphorin 3A, Phosphorylation, Nerve Tissue Proteins - metabolism, 167821-03-6, Dentritic spines, Dendrites - physiology, Neurite outgrowth, Brain, 516536-20-2, Cyclin-Dependent Kinase 5, Brain - enzymology, Dendrites, 57657-35-9, Synapses - physiology, Synapses, Semaphorin 3A, 167821-03-6, 516536-20-2, Cyclin-Dependent Kinase 5, 2.7.1.37, Human
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