The function of vascular endothelial growth factor

descriptionPublicationkeyboard_double_arrow_right Article 04 May 2009 English Publisher:WileyJournal:BioFactors, volume 35, pages 332-337 (issn: 0951-6433, eissn: 1872-8081,

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Authors: Bonnie J, Nieves; Patricia A, D'Amore; Brad A, Bryan;

doi: 10.1002/biof.46

pmid: 19415738

pmc: PMC8265599

The function of vascular endothelial growth factor

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Abstract

AbstractVascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current understanding of VEGF signaling and discusses the benefits and unexpected side effects of promising anti‐angiogenic therapeutics that are currently being used to inhibit neovacularization in tumors. © 2009 International Union of Biochemistry and Molecular Biology, Inc.

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Keywords

Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Neovascularization, Pathologic, Neovascularization, Physiologic, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Receptor-2, Receptors, Vascular Endothelial Growth Factor, Neoplasms, Animals, Humans, Signal Transduction

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