Gelatinases (MMP2 and MMP9) in swine antral follicle

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2011 Italy English Publisher:WileyJournal:BioFactors, volume 37, pages 117-120 (issn: 0951-6433, eissn: 1872-8081,

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Authors: BASINI, Giuseppina; BUSSOLATI, Simona; BAIONI, Laura; GRASSELLI, Francesca;

doi: 10.1002/biof.153

pmid: 21488134

handle: 11381/2363086

Gelatinases (MMP2 and MMP9) in swine antral follicle

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Abstract

AbstractFollicular growth is allowed by extracellular matrix remodeling and vascular network development. Since matrix metalloproteinases (MMPs) play a crucial role in both of these processes, the aim of the present study was to evaluate the expression of gelatinases MMP2 and MMP9 in swine ovarian follicle (theca and granulosa compartments) during its development. Moreover, we measured gelatinase activities into follicular fluids (FF). Our data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers; moreover we show that the expression of both gelatinases increases in theca while decreases in granulosa during follicle growth. Additionally, MMP2 activity has been detected in FF. The spatial pattern of expression of gelatinases in swine follicle suggests a differential role during physiological ovarian events.

Country

Italy

Related Organizations

University of Parma
Italy

Keywords

Granulosa Cells, MMP9, Reverse Transcriptase Polymerase Chain Reaction, Swine, swine ovarian follicle, 610, theca layer, Follicular Fluid, Matrix Metalloproteinase 9, Ovarian Follicle, granulosa layer, Animals, Matrix Metalloproteinase 2, Female, MMP2

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