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Biometrical Journal
Article . 2025 . Peer-reviewed
License: CC BY
Data sources: Crossref
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https://dx.doi.org/10.48550/ar...
Article . 2024
License: arXiv Non-Exclusive Distribution
Data sources: Datacite
DBLP
Preprint . 2024
Data sources: DBLP
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Interpretable Machine Learning for Survival Analysis

Authors: Sophie Hanna Langbein; Mateusz Krzyzinski; Mikolaj Spytek; Hubert Baniecki; Przemyslaw Biecek; Marvin N. Wright;

Interpretable Machine Learning for Survival Analysis

Abstract

ABSTRACT With the spread and rapid advancement of black box machine learning (ML) models, the field of interpretable machine learning (IML) or explainable artificial intelligence (XAI) has become increasingly important over the last decade. This is particularly relevant for survival analysis, where the adoption of IML techniques promotes transparency, accountability, and fairness in sensitive areas, such as clinical decision‐making processes, the development of targeted therapies, interventions, or in other medical or healthcare‐related contexts. More specifically, explainability can uncover a survival model's potential biases and limitations and provide more mathematically sound ways to understand how and which features are influential for prediction or constitute risk factors. However, the lack of readily available IML methods may have deterred practitioners from leveraging the full potential of ML for predicting time‐to‐event data. We present a comprehensive review of the existing work on IML methods for survival analysis within the context of the general IML taxonomy. In addition, we formally detail how commonly used IML methods, such as individual conditional expectation (ICE), partial dependence plots (PDP), accumulated local effects (ALE), different feature importance measures, or Friedman's H‐interaction statistics can be adapted to survival outcomes. An application of several IML methods to data on breast cancer recurrence in the German Breast Cancer Study Group (GBSG2) serves as a tutorial or guide for researchers, on how to utilize the techniques in practice to facilitate understanding of model decisions or predictions.

Country
Denmark
Keywords

FOS: Computer and information sciences, Biometry, explainable artificial intelligence, Methodology, interpretable machine learning, Machine Learning (stat.ML), Survival Analysis, survival analysis, Machine Learning (cs.LG), Machine Learning, Methodology (stat.ME), XAI, explainability, Humans, IML

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    popularity
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    Top 10%
    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Average
Average
Green
hybrid
Related to Research communities
Cancer Research