The biology of hepatocyte growth factor/scatter factor

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1992 English Publisher:WileyJournal:BioEssays, volume 14, pages 613-617 (issn: 0265-9247, eissn: 1521-1878,

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Authors: R A, Furlong;

doi: 10.1002/bies.950140908

pmid: 1365917

The biology of hepatocyte growth factor/scatter factor

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Abstract

AbstractHepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The membrane receptor for hepatocyte growth factor/scatter factor has been identified as the c‐met proto‐oncogene product.

Related Organizations

University of Cambridge
United Kingdom

Keywords

Hepatocyte Growth Factor, Protein Conformation, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-met, Proto-Oncogene Mas, Liver Regeneration, Rats, Genes, Animals, Humans, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 7

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