Edited GluR2, a gatekeeper for motor neurone survival?
Copyright policy )Edited GluR2, a gatekeeper for motor neurone survival?
AbstractAmyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder of motor neurones. Although the genetic basis of familial forms of ALS has been well explored, the molecular basis of sporadic ALS is less well understood. Recent evidence has linked sporadic ALS with the failure to edit key residues in ionotropic glutamate receptors, resulting in excessive influx of calcium ions into motor neurones which in turn triggers cell death. Here we suggest that edited AMPA glutamate (GluR2) receptor subunits serve as gatekeepers for motor neurone survival. BioEssays 30:1185–1192, 2008. © 2008 Wiley Periodicals, Inc.
- University of Oxford United Kingdom
- University of Tokyo Japan
- University of Salford United Kingdom
Ions, Motor Neurons, Neurons, Transcription, Genetic, Amyotrophic Lateral Sclerosis, Models, Biological, Permeability, Protein Biosynthesis, Animals, Humans, Calcium, RNA Editing, Receptors, AMPA
Ions, Motor Neurons, Neurons, Transcription, Genetic, Amyotrophic Lateral Sclerosis, Models, Biological, Permeability, Protein Biosynthesis, Animals, Humans, Calcium, RNA Editing, Receptors, AMPA
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