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GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

descriptionPublicationkeyboard_double_arrow_right Article 20 Mar 2007 Spain Publisher:WileyJournal:BioEssays, volume 29, pages 356-370 (issn: 0265-9247, eissn: 1521-1878,

Authors: Bustelo, Xosé R.; Sauzeau, Vincent; Berenjeno, Inmaculada M.;

doi: 10.1002/bies.20558

pmid: 17373658

pmc: PMC1971132

handle: 10261/5126

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

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Abstract

AbstractRho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.

Country

Spain

Related Organizations

Spanish National Research Council
Spain
University of Salamanca
Spain

Keywords

rho GTP-Binding Proteins, Gene Expression Regulation, Transcription, Genetic, Animals, Phylogeny, Protein Binding, rac GTP-Binding Proteins

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