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Article . 2023
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BioEssays
Article . 2023 . Peer-reviewed
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BioEssays
Article . 2023
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Epigenetic programming in the ovarian reserve

descriptionPublicationkeyboard_double_arrow_right Article 07 Jul 2023 United States English Publisher:WileyJournal:BioEssays, volume 45 (issn: 0265-9247, eissn: 1521-1878, Copyright policy )Funded by:NIH | Epigenetic gene regulatio..., NIH | Ovarian reserve formation...
Authors: Mengwen Hu; Richard M. Schultz; Satoshi H. Namekawa;

doi: 10.1002/bies.202300069

pmid: 37417392

pmc: PMC10698196

Epigenetic programming in the ovarian reserve

Abstract

AbstractThe ovarian reserve defines female reproductive lifespan, which in humans spans decades. The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic prophase I and is maintained independent of DNA replication and cell proliferation, thereby lacking stem cell‐based maintenance. Largely unknown is how cellular states of the ovarian reserve are established and maintained for decades. Our recent study revealed that a distinct chromatin state is established during ovarian reserve formation in mice, uncovering a novel window of epigenetic programming in female germline development. We showed that an epigenetic regulator, Polycomb Repressive Complex 1 (PRC1), establishes a repressive chromatin state in perinatal mouse oocytes that is essential for prophase I‐arrested oocytes to form the ovarian reserve. Here we discuss the biological roles and mechanisms underlying epigenetic programming in ovarian reserve formation, highlighting current knowledge gaps and emerging research areas in female reproductive biology.

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United States
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Keywords

570, 1.1 Normal biological development and functioning, epigenetic reprogramming, Reproductive health and childbirth, Medical and Health Sciences, Epigenesis, Genetic, 618, ovarian reserve, Mice, Genetic, Pregnancy, Genetics, 2.1 Biological and endogenous factors, meiosis, Humans, Animals, Ovarian Reserve, oogenesis, Contraception/Reproduction, Psychology and Cognitive Sciences, epigenetic programming, Biological Sciences, Stem Cell Research, Chromatin, Polycomb, Biological sciences, Meiosis, Infertility, Oocytes, Women's Health, Female, Generic health relevance, Epigenesis, Developmental Biology

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 13
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Top 10%
Average
Top 10%
Green