Pharmacokinetic aspects of the sublingual administration of vincamine

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1990 English Publisher:WileyJournal:Biopharmaceutics & Drug Disposition, volume 11, pages 279-309 (issn: 0142-2782, eissn: 1099-081X,

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Authors: J M, Aiache; M C, Delatte; P P, Leblanc; J P, Kantelip; R, Gomeni; J L, Steimer;

doi: 10.1002/bdd.2510110402

pmid: 2340347

Pharmacokinetic aspects of the sublingual administration of vincamine

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Abstract

AbstractThe sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.

Related Organizations

Université Laval
Canada
French Institute of Health and Medical Research
France

Keywords

Adult, Male, Administration, Sublingual, Administration, Oral, Models, Biological, Vincamine, Random Allocation, Intestinal Absorption, Humans, Vinca Alkaloids

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